How good to see the tradition of excellent office-based research on streptococcal illness in Rochester, NY, being continued by Pichichero et al.1 A question comes to mind, however, in reading the article, which evaluates different oral penicillin treatment regimens used to eradicate streptococci in the oropharynx. To what extent might the results have been influenced by whether the penicillin got into the stomachs of the children who were studied? The authors describe an excellent method of assessing adherence to prescribed medications in the "Methods" section, but no results of that assessment are provided.
Bergman AB. Variables Influencing Penicillin Treatment Outcome. Arch Pediatr Adolesc Med. 2000;154(1):91. doi: