Lipoprotein(a) (Lp[a]) levels are known to be mainly genetically determined. A pentanucleotide repeat polymorphism, (TTTTA)n, 1.4 kilobases upstream from the gene reading frame has been studied as a possible influence in Lp(a) levels.1 To date, repeat sequences ranging from 5 to 12 have been found, with the 8-repeat sequence the most common. Alleles containing more repeats are usually associated with lower Lp(a) levels. The influence of the pentanucleotide repeat on Lp(a) seems to be independent from other polymorphisms.1,2 To our knowledge, this is the first study to assess the influence of this polymorphism in an obese pediatric population.
Nascimento H, Silva L, Lourenço P, Vieira E, dos Santos R, Rego C, Ferreira H, Quintanilha A, Santos-Silva A, Belo L. Lipoprotein(a) Levels in Obese Portuguese Children and Adolescents: Contribution of the Pentanucleotide Repeat (TTTTA)n Polymorphism in the Apolipoprotein(a) Gene. Arch Pediatr Adolesc Med. 2009;163(4):393–394. doi:10.1001/archpediatrics.2009.17