A meta-analysis by Goldstein and colleagues1 nicely summarized that rectal acetaminophen can reduce fever, and though it is not believed to alter the course of infectious illness, we can assume it provides symptomatic relief. However, we find their call for the American Academy of Pediatrics to revise their recommendations pertaining to rectal acetaminophen in children to be premature, and their suggestion for more studies “evaluating possible pharmacodynamic differences in toxic effects between oral and rectal acetaminophen” to be slightly misplaced.
Osterhoudt KC, Henretig FM. Still Wary of Rectal Acetaminophen. Arch Pediatr Adolesc Med. 2009;163(5):491-492. doi:10.1001/archpediatrics.2009.81