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The Pediatric Forum
May 4, 2009

Still Wary of Rectal Acetaminophen—Reply

Arch Pediatr Adolesc Med. 2009;163(5):491-492. doi:10.1001/archpediatrics.2009.82

In reply

We thank Drs Ousterhoudt and Henretig for their comments. The American Academy of Pediatrics' recommendation to refrain from rectal acetaminophen was based on pharmacokinetic studies showing great variation of peak levels of acetaminophen administered rectally, often not achieving therapeutic levels, with longer time to peak concentrations.1 Our meta-analysis showed that pharmacodynamic variables, such as temperature reduction, were similar with rectal and oral administration.2

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