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The Pediatric Forum
July 6, 2009

Universal Primer Polymerase Chain Reaction Looks Promising for Newborns With Low Pretest Probability of Sepsis—Reply

Arch Pediatr Adolesc Med. 2009;163(7):675-676. doi:10.1001/archpediatrics.2009.122

In reply

Drs Newman and Kohn believe that our conclusion that universal PCR is not accurate enough to withhold antibiotic therapy in neonates undergoing evaluation for sepsis is too pessimistic. Specifically, they contend that universal PCR might prove useful in the normal newborn nursery, where studies have shown the risk of sepsis in asymptomatic infants to be as low as 1%.1

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