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The Pediatric Forum
April 5, 2010

Can the Efficacy of Hypertonic Saline in Bronchiolitis Truly Be Assessed With a Short-term Primary Outcome?

Author Affiliations

Author Affiliations: Emergency Department, Manchester Royal Infirmary, Manchester, England (Dr Horner); Blackpool Fylde and Wyre National Health Service Foundation Trust, Blackpool, England (Dr Bartram); and Royal Manchester Childrens Hospital, Manchester (Drs Jenner and Morton).

Arch Pediatr Adolesc Med. 2010;164(4):395. doi:10.1001/archpediatrics.2010.36

Grewal et al1 should be congratulated for their recent study concerning the use of 3% hypertonic saline in the treatment of bronchiolitis. It is refreshing to see such a well-conducted pediatric trial based in the emergency department (ED). We would, however, make several points regarding the methodology of the study and raise concerns about the ultimate message. We believe that the efficacy of the treatment must be looked at in the wider context of the patient journey.

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