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The Pediatric Forum
July 5, 2010

Analysis of Metformin Treatment for Adolescent Obesity at 48 Rather Than 24 Weeks After Treatment Cessation—Reply

Arch Pediatr Adolesc Med. 2010;164(7):678-679. doi:10.1001/archpediatrics.2010.111

In reply

Both the conception of the study by the investigators and its subsequent selection by the Glaser Pediatric Research Network in 2001 were driven by the publication of a series of small, uncontrolled trials of metformin in obesity and/or insulin-resistant adolescents. We agree that lifestyle inventions for obese adolescents are important and thus designed our trial such that both metformin and placebo groups received the identical lifestyle intervention.

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