HYPOXIC ISCHEMIC encephalopathy (HIE) is an important clinical problem in perinatal medicine. Until recently, very little could be done to prevent the devastating sequelae of this condition. Recent advances such as cooling strategies hold promise in this field but they require early identification and intervention.1,2 It still remains difficult to predict which infants will have long-term neurologic sequelae from HIE.3,4 Having a useful marker for a poor neurologic outcome is urgently needed. In the article by Gazzolo et al,5 urinary S100B protein concentrations are used as a marker for brain damage in asphyxiated infants.
Dennery PA. Predicting Neonatal Brain InjuryAre We There Yet?. Arch Pediatr Adolesc Med. 2003;157(12):1151-1152. doi:10.1001/archpedi.157.12.1151