Background: Topical fluoride therapy in the form of varnish, gel, mouth rinse, or toothpaste has been used extensively as a caries-preventive intervention for more than 3 decades.
Objectives: To determine the effectiveness and safety of fluoride varnishes, gels, mouth rinses, and toothpastes in the prevention of dental caries in children and to examine factors potentially modifying their effect.
Search Strategy: We searched the Cochrane Oral Health Group’s Trials Register (May 2000), the CENTRAL Database of Controlled Trials (Cochrane Library, Issue 2, 2000), MEDLINE (1966 to January 2000), plus several other databases. We handsearched journals and reference lists of articles and contacted selected authors and manufacturers.
Berg JH. Good Evidence for Incremental Preventive Benefit of Topical Fluoride Therapies. Arch Pediatr Adolesc Med. 2005;159(4):315-316. doi:10.1001/archpedi.159.4.315