We are concerned about “Antipyretic Treatment in Young Children With Fever: Acetaminophen, Ibuprofen, or Both Alternating in a Randomized, Double-Blind Study” reported by Sarrell et al1 in the February issue of the ARCHIVES. The alternating of acetaminophen and ibuprofen for treating fever in children may cause parental confusion. The parent may give the child acetaminophen, acetaminophen, ibuprofen, ibuprofen rather than acetaminophen, ibuprofen, acetaminophen, ibuprofen.
Saphyakhajon P, Greene G. Alternating Acetaminophen and Ibuprofen in Children May Cause Parental Confusion and Is Dangerous. Arch Pediatr Adolesc Med. 2006;160(7):757-758. doi:10.1001/archpedi.160.7.757-b