January 1951


AMA Am J Dis Child. 1951;81(1):15-17. doi:10.1001/archpedi.1951.02040030022003

UNDER the term acute glomerular thrombosis we report briefly two cases that have certain similarities to the cases of symmetrical necrosis in that the intrarenal blood flow is interrupted but differ from them in that the site of the circulatory obstruction is clearly in the glomeruli and the mechanism consists in the formation of thrombi in the glomerular capillary loops. The condition, which seems to represent a complication of certain severe bacteremias and appears to depend on the presence of micro-organisms within the glomerular capillaries, has received little attention since Blackman and Rake1 described it under the title "acute pneumococcal nephritis." One of the cases (case 4) reported as symmetrical cortical necrosis in a young infant by Campbell and Henderson2 seems to fall in this category.

Since the renal lesion is associated with severe infection, the development of clinical manifestations is often cut short by death of the

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