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Article
January 1951

III. ARTERIOLAR NECROSIS (ACUTE MALIGNANT HYPERTENSION)

AMA Am J Dis Child. 1951;81(1):18-21. doi:10.1001/archpedi.1951.02040030025004
Abstract

ARTERIOLAR necrosis of the kidneys is a lesion found characteristically in malignant hypertension. To our knowledge this condition has not been previously reported as occurring in infancy.

Our case material includes two cases of arteriolar necrosis. One of these, case 14, has been reported elsewhere in detail.1 This was an instance of a peculiar glomerulonephritis in an 8 year old boy who after nephrectomy for an embryoma of one kidney had received intensive radiation therapy over an area that included the remaining kidney. He had died with signs of hypertension and renal failure. The glomeruli were found to be obliterated, and the tubules, dilated and atrophic, and the arterioles throughout showed fibrinoid necrosis and often were surrounded by small hemorrhages. The vascular changes were interpreted as secondary to the combination of hypertension and uremia resulting from the severe generalized glomerular obstruction.

The second case in this group concerns an

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