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Article
February 1951

Streptomycin und die Behandlung Haematogener Tuberkuloseformen.

AMA Am J Dis Child. 1951;81(2):311-312. doi:10.1001/archpedi.1951.02040030320016

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Abstract

The monograph begins with a history of streptomycin, then its chemical formula is given, together with some general considerations. The production and the pharmacologic aspects are described, as well as directives for streptomycin treatment for tuberculosis and other diseases. To dosage, determination of streptomycin levels and the method of testing the sensitivity of tubercle bacilli to the drug, separate chapters are devoted. Chapters on the mechanism of its activity, its toxicity and hypersensitivity to the substance precede one describing experiments on tuberculous animals treated with streptomycin alone or in combination with sulfonamides. Streptomycin resistance is well discussed. The results reported from other countries with the treatment of miliary tuberculosis of the lungs and tuberculous meningitis are given. In the latter the additional intraspinal administration is outlined. These chapters make up 88 of the 179 pages. A number of the author's own patients with miliary tuberculosis, 11 in all, without meningitis,

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