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June 1951

Reports on Biological Standards: VI. The Design of Toxicity Tests.

AMA Am J Dis Child. 1951;81(6):871. doi:10.1001/archpedi.1951.02040030885025

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This is a report on biologic standards and is not likely to attract the interest of the average physician. The subject matter is highly technical, and there is free use of logarithms and symbols. The author states that "the purpose of this report is to review information on the design of toxicity tests and to assess the relative merits of each design."

There is an intricate discussion of the quantal response method and the graded response method for determining toxicity of drugs. The relative value of each is disclosed. In conclusion it is stated that toxicity test should whenever possible be based on a graded response method; recourse to quantal response methods is necessary only when the use of a graded response method is impracticable.

There is a glossary of terms used in the text.

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