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In this monograph the author presents a concise and comprehensive review of the literature, including historical data, statistical material as to the distribution and frequency of the condition and a wealth of descriptive detail concerning the various physical characteristics and pathological findings associated with mongolism. Such aspects of the problem as prognosis and possibilities for treatment and training of children so affected are also discussed. In the closing chapter, which is concerned with etiology, past and present day theories are reviewed. Evidence is presented to disprove many of them, e. g., heredity, consanguinity, specific maternal disease and endocrine dysfunction; the idea that the condition is caused by noxious influences on the uterine mucosa, interfering with blood supply and proper nutrition of the developing embryo, is supported. The author apparently feels very strongly that this is the one and only causative factor, whether as the result of exhausting maternal disease, poisonous
Mongolism: Peristatic Amentia.. AMA Am J Dis Child. 1951;82(1):108. doi:10.1001/archpedi.1951.02040040115014