December 1951


Author Affiliations

From the Pediatrics Department of the Maimonides Hospital.

AMA Am J Dis Child. 1951;82(6):710-716. doi:10.1001/archpedi.1951.02040040731006

IN THE year 1945 Caffey and Silverman1 first described a new syndrome which they called "infantile cortical hyperostosis." At about the same time Smyth, Potter, and Silverman2 reported independently a group of cases with similar changes under the title of "Periosteal Reaction, Fever and Irritability in Young Infants." Ross and Burke3 suggested the name Caffey-Smyth for this new syndrome. It is a distinct clinical entity occurring in early infancy, usually before 3 months of age. It is characterized by a typical facial appearance, swelling of soft tissue, and roentgenographic changes in various bones, especially mandible, clavicles, scapulas, and ribs. Most of the cases have associated fever, anemia, and irritability. The etiology of the disease is obscure. The active manifestations subside completely after a variable period, usually within weeks, with no serious complications and no sequelae. The condition is now known to be not uncommon in pediatrics. We

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