MARKED changes may occur in the blood proteins in many diseases; these changes have long been noted in tuberculosis. Adler,1 in 1925, found an increase in the globulin fraction in pulmonary tuberculosis related to the severity of the tuberculous process. Luthy2 studied the serum proteins in tuberculosis in 1927 and found that at first there were normal protein values, but as the process extended these were increased, and during the final stages of the disease there was a decrease to subnormal values. When the albumin-globulin quotient was considered, this was found to be of much greater significance: increasing globulin content seemed to indicate increasing severity of the pathologic process.
Olivier,3 in 1931, considered the proteins as buffers and changes in protein level as representing attempts to maintain the pH. Normal protein values were found in mild cases, an increase in severe cases or aggravation, and a decrease
LEVIN BM, KAUFMAN H, DE LA HUERGA J. GAMMA GLOBULIN STUDIES IN TUBERCULOSIS IN CHILDREN. AMA Am J Dis Child. 1952;83(1):26-36. doi:10.1001/archpedi.1952.02040050042005