February 1952


Author Affiliations

From the Department of Pediatrics of the Presbyterian Hospital and of the University of Illinois.

AMA Am J Dis Child. 1952;83(2):156-163. doi:10.1001/archpedi.1952.02040060022003

CHRONIC panniculitis with leucopenia (Weber-Christian syndrome) is characterized by recurrent crops of subcutaneous nodules which occur during febrile periods and shows on histological examination a particular kind of fat atrophy. Weber1 described this in 1925, giving it the name of "relapsing nonsuppurative nodular panniculitis." He considered this disease as similar to those described by Pfeifer2 in 1892 and Gilchrist and Ketron3 in 1916. Later, in 1928, Christian4 added the word "febrile" to Weber's original title. Since that time the term Weber-Christian disease, or occasionally syndrome, has been used to describe the condition. Few cases have been reported as acute or chronic panniculitis.

Fifty-six cases similar to that originally described by Weber have been reported since that time. Our reason for reporting the present case is that, in a review of the literature on chronic panniculitis of the Weber-Christian type, this is the second recorded instance in

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