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This short monograph deals with the fundamentals of developmental physiology pertaining to respiration. It begins by describing the fetal-maternal relationships in the developing placenta, then discusses the characteristics of the blood of the fetus and of the newborn, the fetal circulation and the changes that take place at birth, and the conditions of intrauterine respiration, such as blood flow through the placenta, oxygen consumption and cardiac output in the fetus, blood pressure and vascular reflexes, fetal hemoglobin and oxygen capacity of fetal blood, and oxygen content and saturation of fetal blood. Fetal respiratory activity and the mechanisms involved in the initiation of air breathing together with experimental evidence are concisely discussed and summarized. Finally the results of asphyxia are considered, not only in relation to fetal and neonatal death, but also in regard to the effects upon brain tissue and the resultant handicaps in the lives of those who survive
Asphyxia Neonatorum.. AMA Am J Dis Child. 1952;83(2):270. doi:10.1001/archpedi.1952.02040060136012