PERSISTENT and marked eosinophilia of the blood is found in a variety of conditions, including parasitic infections, various skin diseases, allergic conditions, periarteritis nodosa, dermatomyositis, erythema multiforme, leukemia, Hodgkin's disease, rheumatoid arthritis, and convalescence after various infectious diseases; but there still remain isolated cases in which extreme eosinophilia occurs but which do not seem to fit any of the above categories. These have been classified as extreme eosinophilia and leucocytosis,1 eosinophilia with splenomegaly,2 chronic eosinophilia,3 Löffler's syndrome,4 eosinophilia leucemoides,5 and familial eosinophilia.6 However, it would appear that they may all be part of a clinical entity which was recently described by Zuelzer and Apt7 under the title "Disseminated Visceral Lesions Associated with Extreme Eosinophilia."
The purpose of this paper is to present the case of a 27-month-old child in which there were many of the clinical and laboratory findings described by Zuelzer and
SILVER HK, HENDERSON P, CONTOPOULOS A. EXTREME EOSINOPHILIA, INCREASED BLOOD HETEROPHILE-AGGLUTINATION TITER, AND HYPERGLOBULINEMIA. AMA Am J Dis Child. 1952;83(5):649-653. doi:10.1001/archpedi.1952.02040090095011