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Article
August 1952

LACK OF EFFECT OF SUPPLEMENTARY VITAMIN B12 ADMINISTERED TO PREMATURE INFANTS

Author Affiliations

BALTIMORE
From the Division of Pediatrics, Baltimore City Hospitals, and the Department of Pediatrics, The Johns Hopkins University School of Medicine (Dr. Finberg), and the Department of Biochemistry, School of Hygiene and Public Health, Johns Hopkins University (Dr. Chow).

AMA Am J Dis Child. 1952;84(2):165-167. doi:10.1001/archpedi.1952.02050020029002
Abstract

REPORTS of several investigators have indicated that vitamin B12 has growthpromoting properties.1 The possibility that this compound might be of especial benefit to premature infants, as an accelerator of growth and hematopoiesis, has been put to test by a number of clinics, with entirely negative results.2

The present study is concerned with 117 infants admitted to the premature nursery of Baltimore City Hospitals in 1950. Studies were made of the weight gain, the hemoglobin levels, and the red blood cell counts of two groups of premature infants; one group comprised infants who received a daily oral supplement of 30 μ of a solution of crystalline vitamin B12, and the other was a control group.

METHODS  Upon admission to the premature nursery infants were assigned alternately to the vitamin B12 group and to the control group. All infants received similar care during the first week of life.

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