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Article
August 1952

FOUR SIBLINGS WITH HEPATIC DISEASE LEADING TO CIRRHOSIS

Author Affiliations

MINNEAPOLIS
From the Department of Pediatrics and the Dight Institute of Human Genetics, University of Minnesota.

AMA Am J Dis Child. 1952;84(2):168-174. doi:10.1001/archpedi.1952.02050020032003
Abstract

CIRRHOSIS been frequently reported in children, and reference has often been made to multiple cases in families. However, the familial and genetic aspects of cirrhosis are not generally recognized. It is the purpose of this communication, first, to report the histories of four sisters all of whom were seen by one of us (L. F. R.) and who died within the first three months of life with postmortem findings of cirrhosis of the liver, and second, to evaluate briefly familial factors underlying cirrhosis of the liver in children.

REPORT OF CASES  The parents of these children were of primarily Scandinavian extraction, unrelated by blood, and in good health. The mother's first pregnancy resulted in a boy infant who showed no abnormalities and is now living and well.Case 1.—As a result of the second pregnancy, which was normal, a full-term girl was born Jan. 4, 1934, with a birth weight

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