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August 1952


Author Affiliations

From the Medical Service, Children's Medical Center; the Department of Pediatrics, Beth Israel Hospital, and the Department of Pediatrics, Harvard Medical School.

AMA Am J Dis Child. 1952;84(2):175-183. doi:10.1001/archpedi.1952.02050020039004

EVIDENCE of hepatic dysfunction in infectious mononucleosis in adults has been well established. Pfeiffer,1 in his original description of glandular fever in 1889, mentioned enlargement of the liver as one of the major physical findings in the disease. Snapper and his co-workers2 in Europe and Downey and McKinlay3 in this country first described the presence of jaundice in a patient with infectious mononucleosis. Wechsler and Rosenblum4 have shown that in an epidemic of 556 cases, jaundice developed in 7.5% of the patients. Studies of pathology have confirmed the presence of liver changes in infectious mononucleosis and suggested that they are similar to those seen in viral hepatitis.5

Cohn and Lidman6 first demonstrated the presence of positive results of liver-function tests in infectious mononucleosis in adults. This work has subsequently

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