ERYTHEMA nodosum has been recognized as a disease entity for more than 100 years. It was first reported by Buillard in 1840, in his classical treatise on acute rheumatic fever. His concept of the disease was generally accepted for a number of years.
The French workers, notably Poncet (1886) and others, as well as Uffeleman (1876), of Germany, were the first to suggest the tuberculous origin of erythema nodosum because they had observed the association of the disease with tuberculosis. Very soon Scandinavian workers, Ernberg in 19331 and Wallgren in 1931 and 1938,2 published reports suggesting tuberculous origin in large series of cases. Their work was significant, as they were dealing with a childhood age group in which the incidence of tuberculin sensitivity is normally much lower than in the adult group. They concluded that the cutaneous eruption occurred early in the disease at the height of the
BOOTH LI. ERYTHEMA NODOSUM. AMA Am J Dis Child. 1953;85(6):648-654. doi:10.1001/archpedi.1953.02050070665003