DURING the course of a study of experimental milk-aspiration pneumonia produced in rabbits by intratracheal injection of human milk, cow's milk, and feeding mixtures,1 it was found that injection of 10 to 20 cc. of the feeding mixtures often caused fatal pulmonary edema within a few minutes. Injections of similar amounts of human or cow's milk rarely produced this effect.
Evaluation of the contents of the feeding mixture suggested that the difference in the effects of the injection of the feeding mixture as compared to injection of
unfortified human milk or cow's milk was due to the larger amount of carbohydrate in the feeding mixture. This led to a more detailed study of the production of acute pulmonary edema by intratracheal injection of feeding mixtures, human milk, cow's milk, and solutions of the carbohydrates present in milk and the common feeding mixtures.
Intratracheal injections of feeding mixture (2
MORAN TJ. PULMONARY EDEMA PRODUCED BY INTRATRACHEAL INJECTION OF MILK, FEEDING MIXTURES, AND SUGARS. AMA Am J Dis Child. 1953;86(1):45-50. doi:10.1001/archpedi.1953.02050080052005