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August 1953

III. Growth and Metabolism Following l-Thyroxine Administration in Thyroid-Ablated Infant Rhesus Monkeys (Macaca Mulatta)

Author Affiliations

From the Department of Pediatrics and Pediatric Section of the Metabolic Unit of the University of California Medical School.

AMA Am J Dis Child. 1953;86(2):147-156. doi:10.1001/archpedi.1953.02050080156002

AS ONE integral in a series of associated studies and reports upon growth - and metabolism in normal and athyroid infant macaque monkeys,1 this communication presents investigations with athyroid infants during short- and long-term periods of therapy with l-thyroxine.

Previously reported studies dealing with such therapy in the athyroid macaque monkey are limited to observations upon surgically thyroidectomized adult animals.2 Fleischmann and co-workers2a observed that creatinuria and a drop in serum cholesterol followed administration of 1.0 mg. of thyroxine to such animals, either before or after surgical thyroidectomy, and that when one of their thyroidectomized animals was given a similar dose its basal metabolic rate increased from 44.1 to 56.8 calories per kilogram of body weight per day. Jailer and co-workers2b also observed a creatinuria and drop in serum cholesterol in two normal and two surgically thyroidectomized adult animals treated with 0.25 mg. of thyroxine daily

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