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Article
August 1953

III. Growth and Metabolism Following l-Thyroxine Administration in Thyroid-Ablated Infant Rhesus Monkeys (Macaca Mulatta)

Author Affiliations

SAN FRANCISCO
From the Department of Pediatrics and Pediatric Section of the Metabolic Unit of the University of California Medical School.

AMA Am J Dis Child. 1953;86(2):147-156. doi:10.1001/archpedi.1953.02050080156002
Abstract

AS ONE integral in a series of associated studies and reports upon growth - and metabolism in normal and athyroid infant macaque monkeys,1 this communication presents investigations with athyroid infants during short- and long-term periods of therapy with l-thyroxine.

Previously reported studies dealing with such therapy in the athyroid macaque monkey are limited to observations upon surgically thyroidectomized adult animals.2 Fleischmann and co-workers2a observed that creatinuria and a drop in serum cholesterol followed administration of 1.0 mg. of thyroxine to such animals, either before or after surgical thyroidectomy, and that when one of their thyroidectomized animals was given a similar dose its basal metabolic rate increased from 44.1 to 56.8 calories per kilogram of body weight per day. Jailer and co-workers2b also observed a creatinuria and drop in serum cholesterol in two normal and two surgically thyroidectomized adult animals treated with 0.25 mg. of thyroxine daily

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