SINCE there is an impression that a practicable vaccine for poliomyelitis is either at hand or immediately around the corner, it may be best to start this discussion with the statement that such a vaccine is not now at hand and that one can only guess as to what is around the corner. The future possibilities of a vaccine for the control of poliomyelitis depend in large measure on what we still must and can learn with the new tools that have become available to poliomyelitis research in the last few years.
The objective is clear: to imitate what nature does for 99 to 99.9% of the population but without incurring the 1 in 100 to 1 in 1,000 risk of paralysis which in many parts of the world is the price for acquiring immunity to poliomyelitis. The knowledge and tools we had only five years ago provided little hope
SABIN AB. PRESENT STATUS AND FUTURE POSSIBILITIES OF A VACCINE FOR THE CONTROL OF POLIOMYELITIS. AMA Am J Dis Child. 1953;86(3):301-310. doi:10.1001/archpedi.1953.02050080311006