October 1953

Growth and Metabolism in Normal and Thyroid-Ablated Infant Rhesus Monkeys (Macaca Mulatta): V. Roentgenographic Features of Skeletal Development in Normal and Thyroid-Ablated Infant Rhesus Monkeys (Macaca Mulatta)

Author Affiliations

From the Department of Radiology, American Cancer Society Fellow in Radiology (Dr. Lusted), and Department of Pediatrics of the University of California School of Medicine.

AMA Am J Dis Child. 1953;86(4):426-435. doi:10.1001/archpedi.1953.02050080438004

IT IS THE purpose of this paper to integrate roentgenologic features of skeletal growth and development in normal and athyroid infant rhesus monkeys with previously reported studies of growth and metabolism in the same animals.1

In the present study, skeletal growth and maturation were evaluated by serial roentgenograms. The roentgenologic features of thyroid deficiency in humans are well described.2 These features, however, have not previously been investigated in subhuman primates.

METHODS AND MATERIALS  Animals.—Six infant rhesus monkeys whose lineage was carefully recorded were obtained for our studies from the indoor macaque colony of Dr. van Wagenen at Yale University.1aAnimals D-766 and C-794 were used as controls throughout the study, while Animal B-767 was used as a third normal control until the age of 162 days at which time it received a thyroid-ablating dose of 1.5 mc. of I131.1b Animal B-767 was thereafter included in

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