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This little book is devoted exclusively to the metabolism and disorders of the metabolism of bile pigment. The little slip of the pen describing the epithelium of the liver as ectodermal had better be corrected. The author leans heavily on Baumgärtel, who sees the difference of the bilirubin giving the direct van den Bergh reaction from that giving the indirect one in that the direct-reacting bilirubin is held in colloidal solution by means of bile acids. In all probability the work of Najjar was not published in time to receive consideration. In a chapter on formal genesis of icterus, a relationship of glycogen metabolism to icterus is stressed, accepting the differentiation of Baumgärtel into glycogenotoxic and plasmatoxic agents. The glycogenotoxic agents produce a high degree of impoverishment of the cell in glycogen with fat infiltration and necrosis. The sugar formed facilitates the entrance of bilirubin into the blood, with usually
Chemie und Klinik der Bilirubinreduktionsprodukte Urobilin und Sterkoblin.. AMA Am J Dis Child. 1954;87(1):122-123. doi:10.1001/archpedi.1954.02050090122019