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Article
September 1954

EFFECT OF ANTIBIOTICS ON NASOPHARYNGEAL FLORA OF PREMATURE INFANTS

Author Affiliations

BOSTON
From the Division of Clinical Laboratories and the Department of Medicine, Children's Medical Center, Boston Lying-in Hospital, and the Department of Pediatrics, Harvard Medical School.; Fellow of the American Association of University Women on leave of absence from The Children's Hospital of the University of Amsterdam, aided by Travel Grant from Fulbright Foundation.

AMA Am J Dis Child. 1954;88(3):339-343. doi:10.1001/archpedi.1954.02050100341006
Abstract

BEGINNING in 1948, infants admitted to the premature nursery of the Infants' Hospital (Children's Medical Center) were routinely given penicillin and either sulfadiazine or streptomycin in relatively large doses for the first 5 to 10 days following admission. The effect upon mortality appears to have been favorable.1 During the same period, similar antibiotics and chemotherapeutic agents have been prescribed for certain infants admitted to the premature nursery of the Boston Lying-in Hospital in whom early rupture of membranes, suspected or actual infection in the mother, or abnormal pulmonary ventilation suggested actual or potential infection in the infant. The present study was undertaken to determine the effect of this regimen upon the aerobic flora of the nasopharnynx in the premature infants cared for in these two nurseries.

Cultures from the nose and throat are frequently sterile during the first 24 hours after birth.* Torrey and Reese3 pointed out that

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