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Article
April 1955

Marfan's SyndromeReport of Five Cases in One Family

Author Affiliations

Pittsburgh

AMA Am J Dis Child. 1955;89(4):414-420. doi:10.1001/archpedi.1955.02050110504002
Abstract

In the year 1896, A. B. Marfan1 first described the skeletal abnormalities of the syndrome which now goes by his name. Achard,2 in 1902, called attention to the marked attenuation of the extremities and their excessive length and because of the spiderlike appearance of the hands, called it arachnodactyly. He also was the first to report the familial occurrence of this disease. Salle,3 in 1912, first noted the association of the ocular and cardiac anomalies (confirmed by autopsy), and he called attention to an increase in the eosinophilic cells in the pituitary. Ormond and Williams4 focused attention on the frequent association of ectopia lentis and other ocular anomalies with arachnodactyly.

Piper and Irvine-Jones,5 in 1926, reported the first case in American literature. They stressed the frequency of association of arachnodactyly with congenital malformations of the heart. Weve,6 in 1931, called attention to the familial

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