April 1955

II. Laboratory Findings

Author Affiliations

From Department of Research Medicine and Children's Hospital of the University of Pittsburgh School of Medicine.

AMA Am J Dis Child. 1955;89(4):442-450. doi:10.1001/archpedi.1955.02050110532006

INTRODUCTION  In the preceding paper the clinical effects of a regimen of cortisone, bed rest, antibiotics, and diets stringently limited in sodium and high in potassium have been described in 53 children in initial attacks of rheumatic carditis.1 The clinical response suggested that such treatment was beneficial and that the treatment program suppressed the disease process. The present paper describes in detail the changes in the routine bacteriological, hematological, biochemical, and related studies conducted prior to, during, and following therapy.

METHODS  In addition to determinations of sedimentation rates, blood cell counts, and urinalyses, nose and throat swabs were cultured for predominant organisms, and antistreptolysin O titers were determined.2 The biochemical studies included measurements of fasting levels of nonprotein nitrogen and sugar in venous blood and of total CO2 content, chloride, sodium, potassium, total protein, albumin, globulin, cholesterol, and phosphorus in serum.3As in the case of

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