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April 1955

Cytomegaly of the Adrenal Gland

Author Affiliations

From the Departments of Pathology and Pediatrics, Children's Hospital; Associate Pathologist (Dr. Beatty) and member of the Pediatric Staff (Dr. Hawes).

AMA Am J Dis Child. 1955;89(4):463-467. doi:10.1001/archpedi.1955.02050110553008

Cytomegaly, a unique and interesting morphologic change seen in the involutional human adrenal gland, was probably first introduced into the English medical literature by Kampmeier, in 1927. It has been further described by Craig and Landing, Potter, and Morrison.

It is the purpose of this paper to present certain observations on this entity gleaned from the autopsy material of the Children's Hospital from 1942 through 1953. During this period 1243 autopsies were performed. Fifty per cent of these autopsies were done on the bodies of infants 6 months of age or less. Eleven cases of adrenal cytomegaly were found.

METHODS  The protocols and tissue sections from 1243 autopsies were reviewed. The tissues were fixed in Zenker's solution, sectioned at 8μ from paraffin blocks, and stained with hematoxylin and eosin in the usual manner. In each case in which the adrenal gland sections revealed cytomegalic change, the clinical case records were

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