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Of the 98 pages of the monograph on icterus gravis neonatorum, 14 are devoted to a historical review. It is stated that since the discovery of the Rh factor, no attention has been given anywhere to the question of whether a pathogenetic relationship exists between Rh-conditioned and other forms of icterus neonatorum which clinically may be very similar or identical. The author utilizes 17 cases of familial icterus gravis neonatorum, of which he was able to observe 7 personally. Various clinical and pathological aspects are discussed including consideration of the capillary fragility, coagulation and bleeding factors, and the multiplication of hematopoietic areas in liver and spleen and the appearance of such areas in other localities. The theme of the presentation is that the main feature in the pathogenesis is to be seen in the disorder of the permeability of the capillaries (permeability pathology of Eppinger). This increased permeability is due
Die Pathogenese des Icterus gravis neonatorum.. AMA Am J Dis Child. 1955;89(4):509. doi:10.1001/archpedi.1955.02050110599018