The intimate relationship between chorea minor and rheumatic fever long has been recognized. The criteria of Jones,1 now accepted as standard for the diagnosis of rheumatic fever, include chorea as a major manifestation. Chorea has been reported to occur in 51% of all rheumatic fever patients during some phase of their illness2 and as the primary manifestation in 20% to 30%.3
Biochemical abnormalities related to adrenal cortex function have been demonstrated to exist in patients with rheumatic fever. These include alterations in the circulating concentrations of certain acute-phase reactants (mucoproteins,* hexosamines,6 and nonglucosamine polysaccharides7) and in the circulating concentrations of adrenal steroids8 and corticotropin (ACTH).9 The purpose of this study was to determine whether similar abnormalities exist in patients with Sydenham's chorea.
MATERIAL AND METHODS
The subjects of this study were 30 children seen at the Salt Lake County General Hospital and in
AINGER LE, ELY RS, DONE AK, BRILL AB, KELLEY VC. I. Evidence of Abnormal Adrenal Cortex Function. AMA Am J Dis Child. 1955;89(5):575-579. doi:10.1001/archpedi.1955.02050110689009