February 1956

The Failure of Hydrocortisone to Affect Neonatal Jaundice

Author Affiliations

Director, Rh Laboratory, and Assistant Director, First and Third Medical Services (Tufts), Boston City Hospital; Assistant Professor of Medicine, Tufts Medical School (Dr. Desforges). Resident, Rh Laboratory, Boston City Hospital (Dr. Villadolid).

AMA Am J Dis Child. 1956;91(2):126-130. doi:10.1001/archpedi.1956.02060020128004

There are several known results of cortisone administration which could be beneficial to patients with erythroblastosis fetalis. These include a lowering of serum bilirubin, an amelioration of hemolysis in acquired hemolytic anemia, and a stimulation of erythropoiesis. For these reasons, and because some reports have suggested that it is a valuable adjunct in the treatment of hemolytic disease of the newborn, its use was evaluated in various types of jaundice occurring during the neonatal period.

METHODS AND MATERIAL  The serum bilirubin was measured by a modification of the method of Malloy and Evelyn,1 with the Coleman Junior spectrophotometer. In most cases, 0.3 ml. of serum was used and observations were made with a microadapter on final volumes of 1.5 ml. at 1 minute and 3.0 ml. at 30 minutes. Rarely, only 0.1 ml. of serum was available and a similar technique was used with greater dilution of the sample.

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