Although C-reactive protein has been known for more than 20 years, general interest in it is of more recent date. This abnormal protein occurs in the blood of patients during the acute phase of certain diseases. It reacts with the C-carbohydrate of the Pneumococcus and was originally found in studies of patients with pneumonia.
A number of investigators have studied the occurrence of C-reactive protein in the serum of patients with rheumatic fever. The other infectious diseases have been less well studied.* Papers have appeared dealing with tuberculosis,5 viral hepatitis,6 and allergy.8
The common diseases of childhood present a group of inflammations in which the occurrence of C-reactive protein (CRP) might be expected. As this is a quick and simple test which might well be useful in diagnosis and treatment, a survey was carried out on patients at Willard Parker Hospital. Not all of these patients were
STEIN E, SMITH JM. C-Reactive Protein in the Acute Phase of the Common Contagious Diseases. AMA Am J Dis Child. 1956;91(2):150-152. doi:10.1001/archpedi.1956.02060020152008