During the last 18 months there has been much interest in the use of chlorpromazine (Thorazine) in the treatment of psychiatric conditions. The many reports * from the American literature refer primarily to its use with disturbed adults. As the drug had been shown to reduce activity in all mental states, with the production of a state of psychic indifference,† interest was aroused in assessing its usefulness in the treatment of emotionally disturbed children. The more recent reports ‡ on the use of chlorpromazine in children refer primarily to its effect on the overactive, aggressive child. The present study was undertaken as a survey of the effects of chlorpromazine on a wide range of severe emotional disturbances. Within the limitations of our material we have tried to delineate the clinical indications for the use of the drug in children, as well as the emotional complications arising from it.
HUNT BR, FRANK T, KRUSH TP. Chlorpromazine in the Treatment of Severe Emotional Disorders of Children. AMA Am J Dis Child. 1956;91(3):268-277. doi:10.1001/archpedi.1956.02060020270008