It is well known that measles encephalitis is frequently followed by serious neurologic residua and that it is associated with an appreciable case fatality rate, variously estimated between 10% and 30%. In an effort to combat this dread complication of measles, many forms of treatment have been introduced from time to time, only to be discarded as experience has shown them to be without value. Of particular interest was a report1 recommending the use of gamma globulin. However, in a recent study by Greenberg and co-workers2 it was shown that gamma globulin has no value in the treatment of measles encephalitis.
The recent studies of Kabat and associates3 and of Moyer and his co-workers4 which show that experimental demyelinating encephalomyelitis can be suppressed by pretreatment with either corticotropin or cortisone made it seem worth while to investigate the value of hormonal therapy in human encephalomyelitis. This
APPELBAUM E, ABLER C. Treatment of measles Encephalitis with Corticotropin ipi. AMA Am J Dis Child. 1956;92(2):147-151. doi:10.1001/archpedi.1956.02060030141006