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The author tells us that the studies presented in this monograph were carried out as a result of his observations on an extremely interesting case of scurvy in a seventeen-year-old girl. The clinical data and the x-ray changes are presented in some detail. The first section of the book deals with a fairly adequate historical review of adult and infantile scurvy together with short chapters on the experimentally produced disease and on the classic x-ray changes.
The major portion of the monograph is taken up with studies of experimental scurvy in the guinea pig and of experimental rickets in the rat. The author has applied certain histochemical techniques to demonstrate glycogen, mucopolysaccharides, and alkaline phosphastase activity. His hypothesis as to the defects in scurvy and rickets is based on the transformation of glycogen to Cori ester and then to glucose and phosphate. Phosphorylase is responsible for the first, alkaline phosphastase
Scurvy as a Skeletal Disease.. AMA Am J Dis Child. 1956;92(2):216-217. doi:10.1001/archpedi.1956.02060030210024