Struma lymphomatosa is characterized as a progressive disease of the thyroid gland of unknown etiology, occurring almost entirely in females. It appears predominantly in middle age. Although there is a divergence of opinion as to whether it is inflamatory in nature, it is generally classified as a form of thyroiditis. The thyroid gland is grossly enlarged, firm, rubbery, and may be lobulated with a scalloped border. The capsule of the gland is intact with no adhesions to underlying or adjacent structures. Both lobes of the gland are involved in almost all cases. Microscopically, there is marked lymphoid infiltration, atrophic follicles with scanty colloid present, and mild fibrosis. Frequently, there are large hyperplastic lymph nodules with germinal centers present.
The patient commonly complains of fullness of the neck and dysphagia. The results of thyroid function tests are variable, and there seems to be no specific diagnostic pattern. Gribetz and co-workers12
RICCA JJ, MORRIONE TG, ADEL H. Struma Lymphomatosa (Hashimoto's Disease)Report of a Case in Thirteen-Year-Old Boy. AMA Am J Dis Child. 1956;92(6):592–595. doi:10.1001/archpedi.1956.02060030586008