MUCH has been written concerning the occurrence of cholelithiasis in patients with congenital hemolytic anemia, but cholelithiasis complicating sickle-cell anemia is rarely encountered.
Weems,1 in 1945, pointed out that gallstones were occasionally found at autopsy in patients with sickle-cell disease, and he described two adults and a 13-year-old boy in whom gallstones had definitely been demonstrated by x-ray. Although no statement was made, it seems fairly safe to assume that these patients had been treated with multiple transfusions, as it is only recently that the trend away from this type of therapy has occurred. In a review of autopsy findings from 44 cases in the literature Weems found 12 instances of cholelithiasis, only one of which was in the age group from 11 to 20 years. He advanced the theory that cholelithiasis was responsible for some of the acute and chronic abdominal symptoms in these cases.
EASTON JG, WRIGHT PM. Cholelithiasis Complicating Sickle-Cell Anemia. AMA Am J Dis Child. 1957;93(1):87-89. doi:10.1001/archpedi.1957.02060040089003