February 1957

Luteinized Cysts in Ovaries of Infants Born of Diabetic Mothers

Author Affiliations

St. Louis
From the Department of Pathology, Washington University School of Medicine.

AMA Am J Dis Child. 1957;93(2):107-109. doi:10.1001/archpedi.1957.02060040109001

Follicular cysts are frequently found in the ovaries of newborn infants; however, luteinization of the theca interna of the cysts has been rarely reported.1 The recent observation of this phenomenon in an infant born of a diabetic mother stimulated us to search our autopsy series for other examples of this association.

Materials and Methods  The autopsy protocols of the Department of Pathology of Washington University School of Medicine from 1910 to 1955 were examined and of these 17,500 autopsies eight newborn girls born of diabetic mothers were found. Microsections or suitably preserved tissue for this study were available from five of these infants, and they comprise the basis of this study. In addition, ovaries taken at the time of autopsy of 92 newborn girls were selected consecutively from our autopsy files from 1942 to 1952 to serve as a control group.The ovaries were imbedded in paraffin, sectioned, and

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