Recent reports have demonstrated that the enteropathogenic serotypes of Escherichia coli (EPEC) are being found in increasingly large numbers of medical centers.1-6 Furthermore, in those centers where a wider experience with new types has been gained, the importance of this group as etiologic agents is becoming more evident.7-11 It is our impression that the EPEC are the commonest recognizable cause of infantile diarrhea. However, we also have seen instances where the EPEC were found in conjunction with Salmonella or Shigella.1, 10,11 This aspect of the problem will be discussed below.
In September of 1955 attempts were made to determine whether or not EPEC were associated with diarrheal disease in infants and children admitted to the Los Angeles County General Hospital. As the study progressed it became apparent that the EPEC were being found at a fairly uniform rate from month to month resulting in an endemic situation
QUILLIGAN JJ, BIDDLE M, DEDRICK JW, SCOTT ML, BURNETT I. Recovery of Enteropathogenic Types of Escherichia Coli from Infants with Diarrhea. AMA Am J Dis Child. 1957;93(4):420-424. doi:10.1001/archpedi.1957.02060040422010