June 1957

II. Laboratory Findings in One Hundred Six Instances

Author Affiliations

From the University of Pittsburgh School of Medicine and the Children's Hospital of Pittsburgh. Established Investigator of the American Heart Association (Dr. Mateer).

AMA Am J Dis Child. 1957;93(6):604-614. doi:10.1001/archpedi.1957.02060040606002

In a previous report we have described the clinical results and the changes in proteinuria in a total of 106 instances of nephrotic syndrome in children treated, usually for 28 days, with corticotropin (ACTH),* 100 to 200 units per day, a very low-sodium high-potassium diet, and penicillin.1 The alterations in the formed elements of the blood, in serum and blood solutes, and in urinary reducing substances and 17-ketosteroids prior to, during, and following therapy are herein presented.

Materials and Methods  Erythrocyte, leukocyte, and differential blood cell counts; the hemoglobin content; the levels of whole-blood nonprotein nitrogen and sugar; the presence of reducing substances in the urine (Benedict's test); the concentrations of carbon dioxide, chloride, sodium, potassium, total protein, albumin, globulin, calcium, inorganic phosphorus, and cholesterol in serum, and the 24-hour excretion rates of urinary 17-ketosteroids were measured at approximately weekly intervals before, during, and after therapy by methods in

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