Because of the relative frequency of pollenosis ("hay fever") in childhood and the tendency for it to be followed by asthma or perennial allergic rhinitis, a critical reevaluation of the treatment of this condition seems indicated.
The purpose of this study was to determine by means of a controlled study the relative value of the three most widely used techniques of hyposensitization therapy.
The protocol for the study was written before the experiment was begun. Population sampling and random selection procedures were previously discussed with a statistician. It was decided that the experimental population be made up entirely of children referred to the pediatric allergy clinic of the Strong Memorial Hospital. The only weed pollen extract to be used was ragweed.As each new patient with a history of pollenosis was referred to the pediatric allergy clinic, he was assigned by strictly random selection procedures to one of the
JOHNSTONE DE. Study of the Role of Antigen Dosage in the Treatment of Pollenosis and Pollen Asthma. AMA Am J Dis Child. 1957;94(1):1–5. doi:10.1001/archpedi.1957.04030020003001