August 1957

Nephrosis in the Newborn InfantA Syndrome Difficult to Explain by Existing Theories of Etiology

Author Affiliations

New Haven, Conn.; Middletown, Conn.
From the Department of Pediatrics, Yale University School of Medicine (Dr. Gruskay), and Pediatric Section, Middlesex Memorial Hospital, Middletown, Conn. (Dr. Turano). Present Address: Harriet Lane Home, Johns Hopkins Hospital, Baltimore (Dr. Gruskay).

AMA Am J Dis Child. 1957;94(2):117-122. doi:10.1001/archpedi.1957.04030030011003

The nephrotic syndrome is an easily recognized condition which is manifested by edema, albuminuria, hypoalbuminemia, and hyperlipemia. The characteristic histological lesion consists of thickening and splitting of the basement membrane of the glomerular tufts with secondary tubular degeneration and lipoid deposition.1 Renal-clearance studies have shown variable results in the acute phase of the disease and moderately to greatly diminished function in the chronic stages.2,3 The disease is commonest between 18 months and 4 years, although occasional cases are seen in other age groups. We have had the opportunity recently to study an infant who developed the first signs of nephrosis at 15 days of life. This is the third such case reported 4,5 of the nephrotic syndrome in the neonatal premature infant and the first in which renal-clearance measurements have been made during the course of the disease process. Such a case may contribute information as to the

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