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January 1958

Epidemic of Diarrhea of the Newborn—Nonassociation of Cytopathogenic Agents

Author Affiliations

From the Child Research Center of Michigan and the Children's Hospital of Michigan.

AMA Am J Dis Child. 1958;95(1):30-34. doi:10.1001/archpedi.1958.02060050032005

Investigations of the past decade have made it clear that certain serotypes of Escherichia coli are capable of causing diarrheal disease in infants. Such enteropathogenic E. coli appear to be responsible for many of the recently studied institutional epidemics1-6 and account for part of the sporadic diarrheas occurring in infancy.7-9 On the other hand, as a result of the development of newer tissue culture techniques, recently discovered viruses have been shown to be associated with diarrheal disease. Thus Ramos-Alvarez10 found a significant relationship between the incidence of certain enteric cytopathogenic human orphan (ECHO) viruses and "summer diarrhea" in infants and children, and Eichenwald et al.11 have recently reported a nursery outbreak in which cytopathogenic agents were recovered from 10 of 12 infants who had diarrhea.

In view of such findings, it has become necessary to examine the possible role of viral agents in all forms of

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