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March 1958

Encephalitis Complicating Attenuated Rubeola

Author Affiliations

Nashville, Tenn.
From the Department of Pediatrics, Vanderbilt University School of Medicine. Present Address: University of Oklahoma School of Medicine, Oklahoma City.

AMA Am J Dis Child. 1958;95(3):270-275. doi:10.1001/archpedi.1958.02060050272007

The value of γ-globulin in preventing or modifying measles has been clearly demonstrated.1 There is also considerable evidence to indicate that modified rubeola is a comparatively mild disease, usually unaccompanied by significant complications.1,2 Only three cases of encephalitis following measles attenuated by γ-globulin have appeared in the literature.3,4,7 Holliday5 refers to two possible instances but states that in neither could a definite diagnosis be made. Gellis6 has information on 10 cases of encephalitis associated with attenuated measles from his own experience and from reports to him from other physicians. However, the diagnosis in all of the reported cases has been based on clinical grounds alone, with no pathological confirmation. It is the purpose of this communication to report two cases of encephalitis complicating rubeola attenuated by gamma globulin. One, that of a child who died on the 36th hospital day with empyema, bronchopneumonia, perforation of

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