March 1958

Ciba Foundation Symposium on The Chemistry and Biology of Purines.

Author Affiliations

Edited by G. E. W. Wolstenholme and Cecelia M. O'Connor. Price, $9.00. Pp. 327, with 124 illustrations. Little, Brown & Company, 34 Beacon St., Boston 6, 1957.

AMA Am J Dis Child. 1958;95(3):340. doi:10.1001/archpedi.1958.02060050342034

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This volume contains the transcript records of the Ciba Foundation Symposium on Purines held in May, 1956. The symposium represented a meeting of the minds of the synthetic chemists and biochemists working in this field.

The purines, essential constituents of nucleic acids, are extensively discussed largely from the point of view of chemical properties, methods of synthesis, and structure. Part of the discussion is devoted to purines in the vitamin B12 series and analogs. The biochemical effects of 6-mercaptopurine are also described, and a chapter is devoted to its use in the treatment of leukemia.

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